The Course Companion

Biological Modeling:
A Short Tour

by Phillip Compeau

with Noah Yann Lee, Chris Lee, Shuanger Li, and Mert Inan

Five chapters. Five biological mysteries. One clean narrative: no installation guides, no sidebars, just the science and the math that illuminates it.

Your purchase keeps the course free.

What's inside

Prologue
Why do zebras have stripes?

We model Turing patterns emerging from reaction-diffusion systems and see how complexity arises from simple molecular rules.

Module 1
How do cells regulate their own genes?

We explore transcription factor networks and the recurring structural motifs that evolution has discovered independently, again and again.

Module 2
How does a bacterium navigate its world intelligently?

We decode E. coli's chemotaxis algorithm: a robust, adaptive exploration strategy built from a handful of proteins.

Module 3
Why did SARS-CoV-2 spread so much more effectively than the original SARS?

We compare coronavirus spike proteins using structural biology and molecular dynamics to understand viral infectivity at the atomic level.

Module 4
How can computers be trained to see as well as a human?

We build a classifier for white blood cell images using PCA and machine learning, constructing a real diagnostic pipeline from scratch.

Publication of Biological Modeling: A Short Tour was funded by several hundred backers through Kickstarter and Indiegogo. We are grateful to every supporter who helped bring the book to life.

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